OMIM Entry - * 601007 - LEPTIN RECEPTOR; LEPR

601007 - LEPTIN RECEPTOR; LEPR - OBR - LEPR By genetic mapping, Tartaglia et al. (1995) demonstrated that the Obr gene is located on mouse chromosome 4, in a 5.1-cM interval that contains the well-characterized recessive obesity mutation, diabetes (db). Chung et al. (1996) developed a genetic map of 1p in the region of the OBR gene.

OMIM Entry - * 613461 - LEPTIN RECEPTOR OVERLAPPING.

LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; 600946) and leptin receptor (OBR, or LEPR; 601007), thereby altering receptor-mediated cell signaling (Couturier et al. 2007; Touvier et al. 2009).

LEPR leptin receptor - Gene - GTR - NCBI

This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have.
NM_002303.5LEPR:c.1968G>C AND LEPTIN. In a study of the relationship between LEPR polymorphisms and glucose and insulin response to an oral glucose tolerance test, Wauters et al. (2001) found an association in postmenopausal women with impaired glucose tolerance of the lys656-to-asn (K656N) polymorphism with fasting insulin.anti-Leptin Receptor Overlapping Transcript LEPROT. anti-Leptin Receptor Overlapping Transcript (LEPROT) Antibodies. LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR\; MIM 600946) and leptin receptor (OBR, or LEPR\; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al. 2007 [PubMed 18042720]\; Touvier et al. 2009 [PubMed.LEPR leptin receptor - Atlas of Genetics and. LEPR (leptin receptor) Identity: Alias_symbol (synonym). LEPR [Mapview hg19] LEPR [Mapview hg38] OMIM: 601007 614963, mediated signaling pathway leptin receptor activity glucose homeostasis identical protein binding receptor complex receptor complex response to leptin negative regulation of gluconeogenesis regulation of bone.Leptin Receptor AssaysLeptin receptor deficiency: A rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism. Sequence Similarities: Belongs to the type I cytokine receptor family. Type 2 subfamily.Anti-Leptin Receptor antibody ab104403Abcam Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway.
  • LEPR - Leptin receptor precursor - Homo sapiens Human.
  • Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors.

    Anti-Leptin Receptor antibody ab216690Abcam

    Flow Cytometry - Anti-Leptin Receptor antibody (ab216690) Flow cytometric analysis of K562 cells labeling Leptin Receptor using ab216690 at 3 μg for 30 minutes, followed by incubation with a conjugated secondary (PE Conjugated) (green) for 30 minutes, compared to control cells (blue), secondary only (light blue) and isotype control (orange).

    RCSB PDB - Gene View - LEPR - leptin receptor

    The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence.

    LEPR peptideLeptin Receptor Peptide-NP_002294.2

    LEPR: the receptor for leptin (obesity factor). A single-transmembrane-domain receptor of the cytokine receptor family. On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for.

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